Do Ketamine Infusions Help Depression?

Mood disorders like anxiety and stress are prevalent, with the U.S. Census Bureau finding a third of Americans are showing signs of depression. The good news is ketamine infusion therapy may help control symptoms of depression or anxiety.


Not all medicine needs to be dispensed orally. Instead, some doctors will administer medications like ketamine by injecting through a patient’s vein intravenously. Years ago, infusion systems could only be used in hospital settings, but now they are also available in standalone clinics and homes administered by specialized nurses or other staff. In newer systems, the ketamine dosage and flow rate are controlled digitally, ensuring you only receive the prescribed amount over a certain time period.


Wrong. That’s one of the great myths about the medicine, that and the one that it’s more known as a club drug than anything else. Don’t kid yourself into believing pop culture myths about ketamine. The drug originated as an anesthetic in 1962 and that’s still its top medicinal use. But ketamine also works as a sedative and is even used to help treat depression when dispensed as a nasal spray or through infusion therapy.


If you watch televised hospital dramas, patients getting treatment intravenously (infusion therapy) is a common sight. But did you ever stop to wonder about the history of the process? Probably not, but that’s ok. Since at least the Middle Ages, mankind had been looking for ways to transfer blood from human to human, mostly to cure or prevent illnesses, oftentimes failing or just being told the attempt was illegal. In the late 17th and early 18th centuries, Sir Christopher Wren made the first successful transfusion machine using a pig’s bladder. The 19th century saw more tweaks to infusion design, and by the mid-20th century, the machines were commonplace in hospitals across the country. But they’re more than just blood transfer devices.


The short answer is yes, most patients who undergo infusion therapy to treat depression experience positive outcomes in a short period of time. But getting to that point is often a long, arduous journey. In fact, COVID-19 has only made it worse. The U.S. Centers for Disease Control and Prevention said that 40 percent of U.S. adults reported mental health issues as of June 2020, coinciding with the pandemic, ruined economy, and social and racial disruptions.
People who are depressed often struggle with symptoms like anger, sadness, fatigue, trouble sleeping, and many others. Women are more likely than men to be depressed, but the illness also affects children and teens. One common storyline in all cases is that mental health disorders can’t be cured, but their symptoms can be treated, often with a combination of psychotherapy and antidepressants or newer therapeutic options like ketamine infusion. But how does ketamine work?


All pain, mental and physical, is controlled by the brain. Though science and medicine have made strides over the last several decades in understanding the relationship between the two, no one knows for certain how to completely regulate the brain’s perception of pain and depression. Understanding the glutamate system is key, as it’s the starting point for the billions of neutrons transmitting information back and forth related to memory, punishment and reward, and moods, for example. When those neurotransmitters are out of whack, trouble starts brewing. Ketamine may strengthen neurotransmitters, thereby soothing common symptoms of depression in the process.


If you’re suffering from depression, you’ll need a diagnosis before treatment begins. First, a medical doctor will give you a physical, inquire about medical history, and run tests that could exclude conditions that could result in depression. Second, or instead of a physical, a therapist will perform a psychological exam focusing on emotions, behavior, and moods. Finally, the outcome of one or both exams is then compared to conditions in the DSM-5 for a formal diagnosis.


Instead of getting help to fight depression, most people do nothing, either out of shame, lack of resources or they don’t recognize there’s a problem. People with mental illness who commit to treatment usually undergo psychotherapy, self-help, take antidepressants, or take medicine. Some try alternatives like ketamine infusion therapy.


If you are suffering from depression, get help, and don’t wait for the symptoms to worsen. Talk with your doctor or mental healthcare professional about therapy or medication best suited to your condition and ask about the health benefits and potential risks of using a newer treatment like ketamine infusion therapy. Contact us today!

what are symptoms of depression for men and women

What Are The Signs of Depression?

Sign of Depression in Men

Depression symptoms and warning signs can vary in men and women. Men also lean to using different coping skills — both healthy and not — than women. We are not sure why men and women can experience depression in a different way. It probably involves several factors, like hormones, brain chemistry, and life experiences.

Like women suffering from depression, men experiencing depression may:

  • Have feelings of sadness, hopelessness, or emptiness
  • Feel very tired
  • Have trouble sleeping or sleep more than normal
  • Not get satisfaction from activities once enjoyable

And there could be other behavioral signs of depression in men that are not recognized, including:

  • Escapist behavior, like devoting considerable time at their job or on sports
  • Physical symptoms, like headaches, digestive trouble, and pain
  • Trouble with drug use or alcohol
  • Controlling, abusive, abhorrent, or violent behavior
  • Irritability or unacceptable anger
  • Risky behavior, like reckless driving
  • Problems controlling their temper or arguing unnecessarily

How Do The Symptoms of Depression Differ for Men And Woman?

Just as men and women experience biological and physical differences, there are also psychological differences and disparities in symptoms related to depression.

  • Women will more likely think deeply if they are depressed
  • Men suffering depression are more prone to abusing alcohol, drugs, and other substances
  • Women can respond inversely to stressful life experiences
  • A man’s symptoms of depression can be difficult for someone to recognize
  • Women are more susceptible than men to suffer from depression and an eating disorder at the same time
  • Both genders might react in a different way to antidepressants
  • Men are more susceptible to committing suicide

Do We Know What Causes Depression?

Science and medicine have yet to root out the exact causes of depression but the search continues. Like many mental health disorders, a range of factors might be involved, including:

Biological differences: Someone with depression appears to have physical differences in their brains. The importance of these changes is still unclear but may ultimately help determine causes.

Brain chemistry: Neurotransmitters are naturally transpiring brain chemicals that probably play a part in depression. Recent studies indicate that variations in the effect and function of neurotransmitters and their normal interaction with neurocircuits engaged in keeping mood stability can play a big role in depression and how it is treated.

Hormone Variations: Variations in the body’s surplus of hormones can be involved in affecting or triggering depression. Hormone changes can happen with pregnancy and through the weeks or months following delivery and due to thyroid trouble, menopause, or any other conditions.

Inherited traits: Depression is more likely in people with blood relatives who also have the condition. Researchers are attempting to locate genes that could be involved in producing depression.

Risk Factors That Can Lead To Depression

Depression normally starts in the teen years but can occur at any age. Women are more frequently diagnosed with depression than men, but this could be simple math – more women are likely to get treatment. Things that seem to boost the chance of triggering or developing depression include:

Certain personality characteristics, like being too dependent and low self-esteem, self-criticism or pessimism
Trauma or stressful events, such as sexual or physical abuse, the passing or death of a loved one, a tough relationship, or money problems
History of additional mental health illnesses, like anxiety disorder, post-traumatic stress disorder, or eating disorders

Getting Treatment for Depression

If you have been diagnosed with depression: High Functioning Depression, or Postpartum Depression for example, a doctor or therapist could recommend psychotherapy or Ketamine Infusions, to help manage symptoms of the condition. Ketamine was first used as a war-time anesthetic, but researchers have uncovered other therapeutic applications, too, notably in boosting neurotransmitters’ performance in the brain.

Do You Need Help With Depression?

If you are suffering from depression, especially in the age of global pandemics, get help before signs and symptoms become so extreme that you cannot function in everyday life. Talk with a doctor or therapist today about available treatment options: Ketamine Therapy for Depression, and ask about the health risks and benefits.

ketamine infusion high functioning depression treatment

What is High Functioning Depression?

The Effects of Depression

Likely, you knew a high achiever once – someone who excelled academically, professionally, socially – and who seemed destined for greatness. But the façade slowly faded under a tidal wave of exhaustion, intense self-criticism, and little or no sense of accomplishment. In the end, this person probably suffered from severe, undiagnosed depression.

What is Depression?

The National Institutes of Health says depression: “(major depressive disorder or clinical depression) is a common but serious mood disorder. It causes severe symptoms that affect how you feel, think, and handle daily activities, such as sleeping, eating, or working. To be diagnosed with depression, the symptoms must be present for at least two weeks.”

Some forms of depression are unique, or they may happen under distinctive conditions and get diagnosed as high-function depression.

What is High Functioning Depression?

Author and therapist Sherry Amatenstein says that “High-functioning depression or dysthymia may be harder to detect than a major depressive disorder (MDD) because the people living with it are often high achievers who make you think everything is all right all the time.”

If this sounds like someone you considered extremely lucky or fortunate in life, then you may understand why depression in all its shades benefits from some form of psychotherapy or medicine like ketamine.

50 Shades of Depression

  • Dysthymia, also called a persistent depressive disorder, is a persistent kind of depression that continues for years and can have trouble effects on work, daily life, and relationships. People with this condition often have trouble being happy even on normally joyous occasions.
  • Major depressive disorder, also called clinical depression, is exemplified by a constant feeling of sorrow or low interest in external stimuli. You might suffer from this if you experience five or more of these symptoms daily for two weeks of more: Feelings of guilt or worthlessness; difficulty focusing; Increase in sleeping; Weight gain or loss; Irritability; Exhaustion and fatigue; and many others.
  • Bipolar disorder, sometimes called manic depression, is a mental condition that causes extreme variations in mood and fluctuations in thinking, behavior, energy, and sleep. With manic depression, you feel more than just having a really bad day – your depression could result in suicidal thoughts that morph into feelings of endless energy and euphoria.
    Women whose birth experience is characterized by anxiety, sadness, or worry for several weeks or longer may be experiencing postpartum depression, which can actually surface before giving birth.
  • Seasonal affective disorder (SAD) is a kind of depression that happens with the change of season. People who deteriorate from SAD see symptoms starting and ending around the same time every year. For some people, symptoms begin around the fall and persist into the winter, though you may come down with SAD in the springtime or summer.
  • Psychotic depression, according to the National Alliance on Mental Illness, affects nearly 20 percent of people suffering depression and includes episodes so serious that they come down with psychotic symptoms or psychotic depression. This is a mental condition typified by disorganized behavior or thinking; false beliefs, often called delusions, or false sounds or sights, most often called hallucinations.

Signs of Depression

Everyone exhibits different signs of depression, but here are the most common ones to watch for:

  • Feelings of tearfulness, sadness, or hopelessness
  • Irritability, furious outbursts, or frustration
  • Loss of pleasure in normal activities, like hobbies, sex, or sports
  • Sleep trouble or sleeping too much
  • Fatigue, lack of energy
  • Changed eating habits and weight loss, or bigger food cravings and weight gain
  • Anxiety, restlessness, agitation
  • Slowed speaking, thinking, or movement
  • Feelings of guilt or worthlessness, obsession with past failures
  • Problems making decisions, thinking, concentrating, and remembering
  • Frequent or recurring thoughts of suicidal thoughts, death, suicide attempts or suicide
  • Unexplained physical aches

How To Diagnose And Treat High-Functioning Depression

As with other mental health illnesses, high-function depression is diagnosed through a multi-step process. First, a medical doctor will perform a physical, ask about you and your family medical history, and look for an underlying cause of depression symptoms. Next, a therapist will perform a psychological evaluation, asking about your thoughts, feelings, and emotions, and whether any mental illness is or was prevalent with blood relatives. Once a diagnosis is confirmed using the DSM-5, your doctor will recommend treatment which could include psychotherapy or ketamine infusion therapy.


If you or a friend is suffering from high-functioning depression or any other mental illness, contact a doctor or therapist to talk about symptoms and what treatment options might help control the depression symptoms. Mental illness is not curable but can be treated with the right combination of psychotherapy and drugs best suited to your unique condition. In Addition to traditional treatment methods, Ketamine Infusions are also showing great results in helping treat depression. If you or a loved one have questions about the clinical use of Ketamine for Depression Treatment please contact us today to learn more.

help a friend with depression treatment in Nashville, TN

How to Help Someone with Depression

When someone is dealing with depression they are often not the only ones who are suffering. Trying to help someone who’s depressed is often a frustrating, confusing experience. You want to see them get better, but at the same time, you don’t want to do anything that might make the situation worse. As a result, interactions can become tense, simply because you’re trying not to make a mistake. And if you do say or do something that’s poorly received, there’s a danger of becoming resentful that your best efforts are not appreciated. So, how to help someone with depression? Mental health professionals suggest you try some of the following methods.

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