Patients will receive infusion therapy in a private room with constant mechanical monitoring of heart rate, pulse, blood oxygen saturation percentages and blood pressure. Infusion therapy means an IV will be placed and an appropriate dose of Ketamine will be administered over a 40 min time frame or longer. Practitioners are able to see a patients vital signs from the monitors at all times from the nursing station. However, patients will notice that a practitioner will enter the patient treatment room several times during the active phase of the infusion to monitor the depth of sedation and ensure patient comfort. Most patients report a relaxing and peaceful experience. Patients will most likely experience changes in vision and their ability to clearly focus on objects or people, speech will be slurred or slowed, most will have an experience of floating or being disconnected. Patients on average should expect to spend 90 to 120 minutes in the office allowing for the check in procedure, the active phase of infusion and recovery time. Patients will need a trusted friend or family member to drive you home after your infusion. Patients may drive and return to work the next day. Patients may have a friend or family member in the treatment room during infusion, but this is not necessary.