Traditional antidepressants can sometimes trigger mania in people with bipolar disorder, which is why bipolar depression is so difficult to treat. Ketamine works on a different system entirely, acting on glutamate to help the brain form new connections, and it can lift depressive episodes quickly. Because of the risk of mood elevation, every bipolar plan at our clinic is overseen by our board certified psychiatrist, Dr. Delvena Thomas, and your dosing is carefully managed.