Hormone pellets are implanted during a 15-minute procedure in your doctor’s office. A small area on the hip or buttock is cleaned, and a local anesthetic is injected to numb the site. Through a small incision, the prescribed number of pellets are implanted in the fatty tissue just below the skin. A sterile dressing is then applied, and you leave the office with instructions to ice the implantation site and keep it dry for a few days. Most people find the procedure to be quick, easy, and pain-free.